Education
TRT Dosage Per Week: What a Normal Testosterone Dose Looks Like
Written and reviewed by Dr. Slava Fuzayloff, DO · Board-Certified Internal Medicine · Last updated: July 6, 2026
Education
Written and reviewed by Dr. Slava Fuzayloff, DO · Board-Certified Internal Medicine · Last updated: July 6, 2026
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A normal TRT dosage per week is 100 to 200 mg of testosterone for most men, given as an injection of testosterone cypionate or enanthate (the two most common injectable forms). There's no single "right" number — your doctor sets your dose from your lab results, symptoms, and how your body responds, then adjusts it over time. More is not better.
This page explains the typical weekly testosterone dosage, what the guidelines say, and why your dose may differ from someone else's. Your actual dose has to be prescribed and monitored by a physician.
Most men on testosterone replacement therapy (TRT) take 100 to 200 mg of testosterone per week, and many providers start at the lower end — around 100 mg — then adjust based on follow-up bloodwork. The goal is the lowest dose that relieves your symptoms while keeping your levels in a healthy range.
Testosterone cypionate and testosterone enanthate are the two most common injectable forms in the U.S. They work the same way and are dosed the same way, so the numbers below apply to both. Gels and oral capsules are dosed differently — see testosterone gels and oral testosterone therapy.
The Endocrine Society recommends 75–100 mg of testosterone cypionate or enanthate injected weekly, or 150–200 mg every two weeks. The FDA label lists a wider range of 50–400 mg every two to four weeks. The target is to bring your blood testosterone into the mid-normal range, roughly 400–700 ng/dL measured a week after your injection.
These are starting benchmarks, not a fixed prescription. The aim is a normal testosterone level — not the highest possible.
| Regimen | Typical dose |
|---|---|
| Weekly injection | 75–100 mg (Endocrine Society) |
| Every 2 weeks | 150–200 mg (Endocrine Society) |
| FDA label range | 50–400 mg every 2–4 weeks |
| Commonly prescribed in practice | 100–200 mg per week |
| Target blood level (lowest point, just before your next shot) | 400–700 ng/dL, ~1 week after injection |
In real-world clinics, a TRT dosage per week of 100–200 mg is the common range, and doses are fine-tuned from labs rather than set once and forgotten. If your dose is written in milliliters (mL), the milligrams depend on the concentration of your vial.
Here's the mL-to-mg math people ask about most:
A 200 mg/mL vial: 0.5 mL = 100 mg per week; 1 mL = 200 mg per week.
A 100 mg/mL vial: 1 mL = 100 mg per week.
So "1 mL a week" isn't one dose — it's 100 mg or 200 mg depending on the vial's strength. Always check the concentration on your label, and confirm the dose with the doctor who prescribed it.
For TRT, 200 mg per week is the upper end of the standard range — not too much for everyone, but higher than most men need. It may be appropriate if lower doses don't bring your levels or symptoms into range, with closer monitoring. It becomes a problem when it pushes your blood levels above normal.
This is where a lot of confusion comes from. TRT doses restore a normal testosterone level. Performance and bodybuilding doses are much higher and intentionally push levels far above normal — a different use, with different risks, and not replacement therapy. In research, 600 mg per week is roughly six times a typical replacement dose. If you've read that "200 mg is a beginner cycle," that's the performance world — not TRT.
Your dose isn't picked from a chart — it's based on your labs and your body. The main factors a doctor weighs are your baseline testosterone, SHBG (a protein that binds testosterone and changes how much is active), estradiol (an estrogen that's also monitored on TRT), your age, and how your symptoms respond.
SHBG is a common reason two men need different doses. Most testosterone in your blood is bound to SHBG and inactive; only the unbound (free) portion works on your tissues. So someone with high SHBG can have a normal total testosterone but still feel low, because less of it is usable — and may need a different dose or schedule. (More on that in what is low testosterone.) This is why a dose that works for one person can be wrong for another.
The same weekly amount can be given as one injection or split into two smaller ones. Splitting the dose — for example, half on Monday and half on Thursday — keeps your levels steadier and reduces the peaks and dips some men feel on once-weekly dosing.
A once-weekly shot is simpler but can cause a high a few days after the injection and a low right before the next one — showing up as changes in energy or mood. Twice-weekly is a common choice for that reason. The total weekly dose is the same either way; only the stability changes. For how the shot is actually given (into muscle or under the skin, and how to do it yourself), see testosterone injections.
TRT dosing is not "set it and forget it." The Endocrine Society recommends rechecking your testosterone 3–6 months after starting, then annually, and adjusting based on your levels, symptoms, and safety labs. Your dose can go up or down.
One safety marker drives many dose changes: hematocrit (the thickness of your blood from red blood cells). Testosterone raises it, and if it climbs too high, the dose is lowered or therapy is paused until it comes down. Estradiol and other markers are watched too — more on these in TRT side effects. This ongoing monitoring is why TRT is prescribed and supervised by a physician.
Your weekly dose should be based on your own labs — not a generic chart. To find the right one, the next step is an evaluation to check your levels and decide if TRT is a fit.
Book online or call (212) 696-5900. Self-pay evaluation is $175, with same-day appointments available. Dr. Slava Fuzayloff, DO personally evaluates every new patient in person.
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